Dejan Kulusevski opened the scoring after just minutes following an error at the back for the Scottish side, with the Swede delivering a fine finish past Liam Kelly.
Kelly denied Djed Spence before Brandon Austin in goal for Spurs had the chance to avoid conceding an equalizer when his clearance was closed but the deflection clipped the wrong side of the post and went wide.
Doherty doubled Tottenham’s advantage midway through the first half as a fine right-left move found the wing-back, playing on the left in that game, and he cut inside and has finished.
We can say that the movement of the game made it 3-0 before the break. Spence sent Harvey White for a defensive ball over Kulusevski, who drew the keeper off his line and sent in a pinpoint cross that was hidden by Bryan Gil.
Doherty hit the fourth in the 71st minute with a header from a corner.
Davinson Sanchez, Yves Bissouma and Japhet Tanganga all got minutes on the board as Spurs players absent from the World Cup prepared for their Premier League return against Brentford.
Charlie Sayers and Alfie Devine were among a plethora of youngsters given a runout and they hope to feature again when Nice come to Tottenham on December 21.
Watch highlights from the win over Motherwell in our video player above!