Casemiro is back from suspension for the Red Devils, who are without Donny van de Beek and Axel Tuanzebe with long-term injuries. Diogo Dalot and Anthony Martial will also be absent.
Jadon Sancho is back in training at Carrington after an absence due to a fitness issue and Erik ten Hag continues to be patient with the player ahead of a possible matchday selection.
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Ten Hag told reporters: “All the players who weren’t available for the Arsenal game, so Dalot, Martial, Sancho, are also not available for tomorrow.”
David De Gea is chosen in goal with Tom Heaton on the bench while Lisandro Martinez keeps his place. Harry Maguire is not on the team.
Marcus Rashford joins a first-choice frontline of available players.
Manchester United XI: De Gea; Wan-Bissaka, Lindelof, Martinez, Malacia; Eriksen, Casemiro; Anthony, Fernandes, Rashford; Weghorst.
Subtitles: Heaton, Varane, Williams, Fred, Mainoo, McTominay, Pellistri, Elanga, Garnacho.