It was feared the striker would have to come off in the derby against Manchester City as he picked up a hip injury late in the first half, although he went on to score the winner at Old Trafford.
Both Rashford and Erik ten Hag played down the ‘hit’ and the United boss is expected to provide an update on his player’s fitness when he faces the media on Tuesday afternoon.
Anthony Martial came off at half-time in the weekend’s win and, although fit, he could find his place under threat from Alejandro Garnacho or even debutant Wout Weghorst.
The Dutch striker is eligible to play at Selhurst Park after coming on loan from Burnley just before the game against City, and he was pictured in training ahead of facing Palace.
Diogo Dalot is likely to miss again while facing an ongoing hamstring complaint. Jadon Sancho, Axel Tuanzebe and Donny van de Beek are long-term absentees.
Once again, Ten Hag will have to decide whether to continue playing Luke Shaw in central defense. On an impressive run down the side, the England defender keeps Lisandro Martinez out of the XI while Tyrell Malacia continues to earn strong reviews at left-back.
The United boss also has a call to make in midfield after starting Fred against City and moving Christian Eriksen down the pitch, dropping Antony in the process.
Predicts Manchester United XI: De Gea; Wan-Bissaka, Varane, Shaw, Malacia; Casemiro, Eriksen; Antoine, Fernandes, Garnacho; Rashford.