Amandine Henry netted a dazzling curling shot in the sixth minute, before Ada Hegerberg headed home a superb cross from Selma Bacha to double Lyon’s lead.
Catarina Macario netted a third from close range before Alexia Putellas netted one for the Spanish giants.
Despite pressure from Barça in the second half, Lyon remained resolute, being crowned European champions once again.
It was the battle of the two greatest teams in women’s football.
Lyon: The seven-time winners are full of experienced winners led by prolific goalscorer Hegerberg.
And Barcelona: The fittest team at the moment, which includes reigning Ballon d’Or Feminin winner Putellas.
The two sides have met in a Champions League final before, with Hegerberg scoring a hat-trick in a 4-1 win at Lyon in 2019. But this time was different.
And with a packed Juventus Stadium in Turin, the hordes of fans were not disappointed.
From minute one, the game was an all-out affair, with both teams’ attacking prowess dominating the proceedings.
But it was a bit of magic – worthy of a final – that got the fans on their feet early on.
Henry, collecting the ball from almost 30 yards, struck a superb long-range shot that fired into the top corner, giving Barca keeper Sandra Paños no chance.
This classy moment from France international Henry opened the door to attacking forays, which Lyon’s experienced leaders took advantage of.
A sumptuous left-footed cross from Bacha was sent home by Hegerberg – the competition’s all-time top scorer – to extend the lead even further.
And the match seemed to be out of sight for defending champions Barca when Macario tapped home from inches away.
But Barca – a team that made history just weeks ago by completing a perfect league campaign of 30 wins from 30 matches – showed talent and courage to gain a foothold.
Putellas’ goal late in the first half gave his side hope before halftime.
After the break it was more or less the same, with chances for both teams, the closest coming when Patricia Guijarro attempted an audacious shot from almost 40 yards out, her effort slamming against the bar before bouncing in completely safe.
Despite pressure from Barcelona, he was unable to materialize any of his chances, meaning Lyon lifted their record eighth Champions League title.
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