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Running back Dalvin Cook is officially inactive for the Vikings’ home opener Sunday afternoon against the Seahawks.

Cook has been sidelined from practice all week with a sprained right ankle sustained at the end of last week’s loss to Arizona. Although coach Mike Zimmer said on Wednesday that the team will “continue to play” Cook despite his latest injury, the centerpiece of the Vikings’ offense will be set aside to heal after being unable to train the entire time. week.

This is the 22nd game that Cook has been ruled out due to an injury in his five-year NFL career and his first absence this season. Only two running backs – Tennessee’s Derrick Henry and Carolina’s Christian McCaffery – entered Week 3 with more scrimmage yards than Cook’s 252 yards.

Running back Alexander Mattison will make his third NFL start, with running back Ameer Abdullah and full-back CJ Ham taking on the rest of the workload. Mattison’s career-high 112 rushing yards were won against the Seahawks last year, when he replaced Cook in the second half and ultimately missed a hole on a key fourth down.

The defensive end’s rotation will be bolstered with the return of Everson Griffen, who was ruled out of the concussion protocol this week. Griffen missed the Week 2 loss in Arizona after a car crash on his way to the team’s headquarters in Eagan.

Three other Vikings were ruled out with injuries to linebacker Anthony Barr (knee), tackle Christian Darrisaw (groin) and cornerback Harrison Hand (hamstring).

The Vikings re-signed Abdullah to the active roster on Saturday and gave up tackle Blake Brandel. Guard Dakota Dozier and cornerback Parry Nickerson moved on from the practice squad to the game day roster.

The inactive Vikings: Cook (ankle), Darrisaw (groin), Barr (knee), Hand (hamstrings), QB Kellen Mond, DE Patrick Jones and DT James Lynch.

Inactive Seahawks: OT Brandon Shell (ankle), RB Rashaad Penny (calf), WR Dee Eskridge (concussion), LB Benson Mayowa (neck), DE LJ Collier, QB Jake Luton and S Marquise Blair.

Seattle will be without Shell, the starting right tackle. Reserve tackle Jamarco Jones is set to get his sixth NFL start against the Vikings.

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