Queensland Police say they are investigating a fatal single-vehicle crash in Hervey Range, about 50 kilometers (31 miles) from Townsville. Emergency services present at the crash had attempted to revive Symonds, but he died of his injuries.
Initial reports said the crash happened shortly after 11pm on Saturday.
Symonds played 26 Test matches for Australia between 2004 and 2008, as well as 198 one-day internationals and 14 Twenty20 internationals.
“The club are shocked and saddened to learn of the passing of former overseas star and cult hero, Andrew Symonds,” the star’s former club Kent Cricket said on Twitter.
“The thoughts of everyone at Kent Cricket are with Roy’s family and friends at this desperately sad time.”
After retiring in 2012, Symonds worked as a TV commentator for Fox Sports.
Symonds is the third Australian cricket icon to die this year after Shane Warne and Rod Marsh.