Russell Wilson threw three of his four first-half touchdowns on Sunday and Seattle cracked down in the second half to close a 28-16 season opener at Indianapolis.
The defending NFC West champions have won 12 of their last 13 games in Sunday morning’s time slot.
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Indy lost their eighth straight opening game, the last five with various starting quarterbacks.
Wilson was sensational in his first act with new offensive coordinator Shane Waldron, destroying a top-10 defense that entered the season with even higher aspirations.
But against Seattle’s revamped offense, Wilson made sure the Colts’ defense never stood a chance.
While he didn’t take any pre-season snaps, the eight-time Pro Bowler led the Seahawks to touchdowns in their first two drives, teaming up with Tyler Lockett on a twist grip over the top. ‘shoulder for a 23-yard TD pass to make it 7-3 and find Gerald Everett for a 9-yard lead to give Seattle a 14-3 lead.
Carson Wentz responded with a 10-yard TD pass to Zach Pascal, reducing Indy’s deficit to 14-10.
But Wilson finished the half with a 69-yard throw to Lockett after breaking free behind two Colts safeties. Wilson finished the half with a perfect passer rating of 158.3 and finished 18 of 23 with 254 yards. His final score of 152.3 was the second highest in his 10-year career and his best score in a September game.
Wilson sealed the win with a 15-yard pass to Pro Bowl receiver DK Metcalf with 6:41 left to make it 28-10.
While the Colts’ defense played better in the second half, the offense stalled. Wentz was under constant pressure and Indy didn’t score until Wentz connected with Pascal on an 11-yard touchdown pass with 2:08 to go.
Wentz was 25 of 38 with 251 yards and two scores in his Colts debut.
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Seahawks: Lockett finished with four receptions for 100 yards while Metcalf caught four passes for 60 yards. … Chris Carson ran 16 times for 91 yards. … Wilson scored his 99th victory. … Seattle is now 1-2 all-time at Lucas Oil Stadium. … Only one of the last six games of this series has been decided by less than seven points.
Colts: Wentz fell to 0-6 against Seattle. … Indy has allowed three sacks after dropping the NFL’s second-lowest number (71) in the previous three seasons. … Jonathan Taylor had 17 carries for 56 yards and six catches for 60 yards. … First-round draft pick Kwity Paye recovered a fumble in his NFL debut.
Seahawks: Receiver Penny Hart did not return after being diagnosed with a concussion. Backup running back Rashaad Penny also left early with a calf injury.
Colts: Indy played without starting cornerback Xavier Rhodes (calf) and four-time Pro Bowl receiver TY Hilton (neck surgery). Cornerback Isaiah Rodgers left briefly in the first half after a punt return, but came back.
Seahawks: Hosts defending AFC South champions Tennessee next Sunday.
Colts: Stay in the NFC West, hosting the Los Angeles Rams next Sunday.