A calf injury suffered against Chelsea led to the defender being retired in the first half of the defeat at Stamford Bridge.
Patrick Vieira confirmed the move after the game but said he was unable to set a timeframe for Andersen’s return, with an update expected when the Eagles boss faces the media on Tuesday.
James Tomkins came on as a substitute at the weekend and will continue to replace United if Andersen misses out.
Vieira’s other selection decisions are largely tactical with James MacArthur and Nathan Ferguson out long term.
Odsonne Edouard is competing to get back in front, allowing Wilfired Zaha to move largely at the expense of Eberechi Eze.
Jordan Ayew and Michael Olise are expected to continue in the starting lineup despite Vieira’s pleas for his side to be more clinical.
Predicted Crystal Palace XI: Guaita; Clyne, Tomkins, Gehi, Mitchell; Doucoure, Schlupp; Ayew, Olise, Zaha; Edward.