The Blues have been using Kepa Arrizabalaga as their No.1 keeper for the past few weeks but a foot injury meant he was sidelined for several days.
It follows a string of impressive performances from Kepa since battling for Mendy’s starting spot after suffering a minor knee injury when Thomas Tuchel was sacked.
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Mendy has since recovered and is part of a strong starting XI in the Champions League, despite first place and qualification for the knockout stages already secured.
Kalidou Koulibaly is back in the starting line-up after a fortnight on the sidelines with a minor knee injury, while Raheem Sterling reportedly starts at right-back with Ben Chilwell on the opposite flank.
Mateo Kovacic is out as the club manage the tightness in his calf and in his absence Denis Zakaria makes his long-awaited debut, partnering Jorginho in midfield.
Starting XI: Mendy, Azpilicueta, Koulibaly, Chalobah, Sterling, Jorginho, Zakaria, Chilwell, Mount, Havertz, Aubameyang
Subtitles: Bettinelli, Silva, Pulisic, Loftus-Cheek, Broja, Ziyech, Gallagher, Cucurella