The centre-back joined Arsenal from Spezia on Monday afternoon, for an initial fee of £17.5million, and is expected to be in the squad for the game at the Etihad.
Arsenal manager Mikel Arteta is likely to make changes to his squad for the clash with City and Leandro Trossard could make his full debut.
“I see a player (Trossard) who is ready to shake things up and is really composed, especially in the final third,” Arteta said.
“It’s something we needed in the team and straight away he had a great impact in the team to help us win.”
Emile Smith Rowe is hoping to make his first start of the season after recovering from a groin injury.
Arteta faces a dilemma over who he starts in goal, with Matt Turner usually giving the nod to Aaron Ramsdale in cup games.
Arsenal probably XI (4-3-3): Turner; Tomiyasu, Holding, Gabriel, Tierney; Vieira, Partey, Xhaka; Trossard, Nketiah, Smith Rowe.
Friday 20:00 GMT, ITV
Location: The Etihad
Arbitrator: Paul Tierney
The Arsenal team of: Huh, Ramsdale, Turner; Cédric, Gabriel, Holding, Kiwior, Saliba, Tierney, Tomiyasu, White, Zinchenko; Elneny, Lokonga, Odegaard, Partey, Saka, Smith Rowe, Trossard, Vieira, Xhaka; Jesus, Martinelli, Marquinhos, Nelson and Nketiah.
Injured: Elneny (knee), Jesus (knee), Nelson (hamstrings)